Department of Clinical Research, U. S. Army Medical Research of Infectious Diseases (USAMRIID), Fort Detrick, MD, USA.
Vaccine. 2013 Oct 17;31(44):5009-14. doi: 10.1016/j.vaccine.2013.08.086. Epub 2013 Sep 8.
We describe the Bacillus anthracis protective antigen IgG antibody response and the B. anthracis lethal toxin neutralization activity to a delayed dose of anthrax vaccine adsorbed (AVA, BioThrax(®)) using validated assays. 373 individuals received 1, 2, or 3 priming doses, 18-24 months afterward, they received a delayed dose of AVA. Overall, 23.6% of subjects showed detectable anti-PA IgG before the boost, compared to 99.2% (P<0.0001) 28 days after the boost. Geometric mean anti-PA IgG concentration (GMC) was 1.66 μg/mL before and 887.82 μg/mL after the boost (P<0.0001). The proportion of individuals with four-fold increase in GMC following the boost ranged from 93.8% to 100%. Robust anti-PA IgG levels and B. anthracis lethal toxin neutralization activity are induced when an AVA dose is delayed as long as two years. These data support continuing with the vaccination schedule when a dose is delayed as long as two years rather than restarting the series.
我们使用经过验证的检测方法描述了炭疽芽孢杆菌保护性抗原 IgG 抗体反应和炭疽芽孢杆菌致死毒素中和活性对延迟剂量炭疽疫苗吸附剂（AVA，BioThrax(®)）的反应。373 名个体接受了 1、2 或 3 次基础剂量，18-24 个月后，他们接受了延迟剂量的 AVA。总体而言，23.6%的受试者在加强针之前可检测到抗-PA IgG，而在加强针后 28 天则有 99.2%（P<0.0001）的人可检测到。加强针前的抗-PA IgG 几何平均浓度（GMC）为 1.66μg/mL，加强针后则为 887.82μg/mL（P<0.0001）。加强针后 GMC 增加四倍的个体比例范围为 93.8%至 100%。当 AVA 剂量延迟长达两年时，会诱导出强大的抗-PA IgG 水平和炭疽芽孢杆菌致死毒素中和活性。这些数据支持在剂量延迟长达两年时继续进行疫苗接种计划，而不是重新开始接种系列。
