Department of Food Science, College of Agriculture, National Pingtung University of Science and Technology, Neipu Township, Pingtung County 91201, Taiwan.
Evid Based Complement Alternat Med. 2013;2013:201643. doi: 10.1155/2013/201643. Epub 2013 Aug 20.
The tuberous root of Liriope spicata var. prolifera (TRLS; Liliaceae family) is valued for the ability to promote glucose homeostasis, and it may therefore be utilized as an adjuvant therapy in the control of diabetic complications. The aim of the present study was to examine the effects of an aqueous ethanol extract from TRLS (TRLS-ext) (100 or 200 mg kg(-1) per day for eight weeks) on rats with streptozotocin-induced diabetic nephropathy (DN). Renal dysfunction in diabetic rats was ameliorated by TRLS-ext as evidenced by reduced creatinine clearance, as well as increased blood urea nitrogen and proteinuria. Treatment with TRLS-ext was found to markedly improve histological architecture in the diabetic kidney. Hyperglycemia induced degradation of inhibitory kappa B and reduced nuclear factor kappa B activation, leading to increased infiltration of macrophages and increased levels of proinflammatory cytokines, including interleukin-1 and tumor necrosis factor- α . All of the above abnormalities were reversed by TRLS-ext treatment, which also decreased the expression of intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and fibronectin in the diabetic kidneys. These findings provide a perspective on the renoprotective effects of TRLS-ext in DN.
石蒜科山麦冬属植物的块根（TRLS）具有促进葡萄糖稳态的能力，因此可作为糖尿病并发症控制的辅助治疗药物。本研究旨在探讨 TRLS 水醇提取物（TRLS-ext）（100 或 200mg/kg/天，连续 8 周）对链脲佐菌素诱导的糖尿病肾病（DN）大鼠的作用。研究结果表明，TRLS-ext 可改善糖尿病大鼠的肾功能，表现为肌酐清除率降低，同时血尿素氮和蛋白尿增加。TRLS-ext 治疗可明显改善糖尿病肾脏的组织学结构。高血糖诱导抑制性κB 降解和核因子κB 激活减少，导致巨噬细胞浸润增加和促炎细胞因子（包括白细胞介素 1 和肿瘤坏死因子-α）水平升高。TRLS-ext 治疗可逆转上述所有异常，还可降低糖尿病肾脏中细胞间黏附分子-1、单核细胞趋化蛋白-1 和纤维连接蛋白的表达。这些发现为 TRLS-ext 在糖尿病肾病中的肾脏保护作用提供了新视角。
