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线性化数学模型在肿瘤血管生成中毛细血管形成的解:初始数据摄动逼近。

Solutions of a linearized mathematical model for capillary formation in tumor angiogenesis: an initial data perturbation approximation.

机构信息

Department of Mathematics, University of Kocaeli, Umuttepe Campus, Kocaeli, Izmit, Turkey.

出版信息

Comput Math Methods Med. 2013;2013:789402. doi: 10.1155/2013/789402. Epub 2013 Aug 18.

Abstract

We present a mathematical model for capillary formation in tumor angiogenesis and solve it by linearizing it using an initial data perturbation method. This method is highly effective to obtain solutions of nonlinear coupled differential equations. We also provide a specific example resulting, that even a few terms of the obtained series solutions are enough to have an idea for the endothelial cell movement in a capillary. MATLAB-generated figures are provided, and the stability criteria are determined for the steady-state solution of the cell equation.

摘要

我们提出了一个用于肿瘤血管生成中毛细血管形成的数学模型,并通过使用初始数据摄动方法对其进行线性化来求解。这种方法对于获得非线性耦合微分方程的解非常有效。我们还提供了一个具体的例子,即使只得到级数解的少数几项,也足以了解毛细血管中内皮细胞的运动。提供了 MATLAB 生成的图形,并确定了细胞方程稳态解的稳定性判据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0e/3762161/3a522cf651c0/CMMM2013-789402.001.jpg

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