Paweletz N, Knierim M
Growth and Division of the Cell Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg, Federal Republic of Germany.
Crit Rev Oncol Hematol. 1989;9(3):197-242. doi: 10.1016/s1040-8428(89)80002-2.
In recent years, tumor-related angiogenesis has become an important field of research in oncology. It could be stated that growth of solid tumors is completely dependent on neovascularization to provide the tumor with all required nutrients. Special compounds (tumor angiogenesis factor[s]) are released by tumor cells into the environment to stimulate different types of normal cells to become active for the tumor. In particular, endothelial cells of neighboring capillaries are induced to react. They disintegrate their own basal lamina, detach from their neighbors, enter the extracellular matrix, and migrate toward the tumor mass. Cell divisions occur within such sprouts, thereby increasing the number of migrating endothelial cells. Strands of such cells are formed, and inter- and intracellular lumina develop. Loops of these hollow strands anastomose to form a network of new vessels which become connected with the blood circulation. The tumor mass thus becomes vascularized and can continue to grow. The prevention of neoangiogenesis has an enormous impact on cancer treatment by inhibiting the growth of the tumor. In this review, all important aspects of tumor-related angiogenesis are presented.
近年来，肿瘤相关血管生成已成为肿瘤学研究的一个重要领域。可以说，实体瘤的生长完全依赖于新生血管形成，以便为肿瘤提供所有必需的营养物质。肿瘤细胞会向周围环境释放特殊化合物（肿瘤血管生成因子），刺激不同类型的正常细胞为肿瘤发挥作用。特别是，邻近毛细血管的内皮细胞会被诱导做出反应。它们分解自身的基底膜，与相邻细胞分离，进入细胞外基质，并向肿瘤块迁移。在这些芽状结构中会发生细胞分裂，从而增加迁移内皮细胞的数量。这些细胞形成条索状，细胞间和细胞内的管腔逐渐形成。这些中空条索状结构的环相互吻合，形成一个与血液循环相连的新血管网络。肿瘤块由此实现血管化并能够继续生长。通过抑制肿瘤生长，防止新生血管生成对癌症治疗具有巨大影响。在本综述中，将介绍肿瘤相关血管生成的所有重要方面。
