Robinson Penelope J, Bell Robin J, Lanzafame Alfred, Kirby Catherine, Weekes Andrew, Piterman Leon, Davis Susan R
Women's Health Research Program, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Servier Laboratories, Melbourne, Victoria, Australia School of Primary Health Care, Monash University, Melbourne, Victoria, Australia.
Australas J Ageing. 2013 Sep;32(3):177-83. doi: 10.1111/j.1741-6612.2011.00553.x. Epub 2011 Jul 25.
To investigate vitamin D status among older women and to explore relationships between vitamin D and fracture risk and vertebral fractures.
A total of 267 general practitioners recruited 2466 women aged >70 years with no known osteoporosis or fragility fracture. Serum 25-hydroxy vitamin D (25(OH)D), bone mineral density by dual-energy X-ray absorptiometry (DXA) and vertebral fracture on thoracolumbar X-ray were determined.
A total of 2368 women, median age 76 years, provided data and of these 13% were on vitamin D supplements. 25(OH)D levels were available for 907 (44.1%) of those not taking vitamin D. 88.3% of these had a level below 75 nmol/L. Serum 25(OH)D was negatively associated with age (P = 0.003) and body mass index (P < 0.001), and positively associated with lower latitude, femoral neck DXA T-score (P = 0.044) and being Caucasian (P < 0.001).
The vitamin D status of community-dwelling older Australian women is inadequate, yet the use of supplements is low.
调查老年女性的维生素D状况，并探讨维生素D与骨折风险及椎体骨折之间的关系。
共有267名全科医生招募了2466名年龄大于70岁、无已知骨质疏松症或脆性骨折的女性。测定血清25-羟基维生素D（25(OH)D）、采用双能X线吸收法（DXA）测定骨密度以及胸腰椎X线检查椎体骨折情况。
共有2368名女性（中位年龄76岁）提供了数据，其中13%服用维生素D补充剂。907名（44.1%）未服用维生素D的女性有25(OH)D水平数据。其中88.3%的女性该水平低于75 nmol/L。血清25(OH)D与年龄（P = 0.003）和体重指数（P < 0.001）呈负相关，与较低纬度、股骨颈DXA T值（P = 0.044）及为白种人（P < 0.001）呈正相关。
居住在社区的澳大利亚老年女性维生素D状况不佳，但补充剂的使用比例较低。
