Keshileva Z B, Kosukhin A B, Polevaia L G
Vestn Dermatol Venerol. 1990(5):7-11.
The findings of examination of patients with disseminated psoriasis vulgaris evidence a reduction of high-density lipoprotein (HDLP) cholesterol in women and of low-density lipoprotein cholesterol in men with type IV hyperlipoproteinemia (HLP) as against the normolipidemic patients. Correlation of serum triacylglycerides and HDLP cholesterol concentration was discovered only in men with type IV HLP (r = -0.72, p less than 0.01), administered lipid-reducing and cytostatic drugs. The period of hospitalization was longer and the remissions less frequent in these patients in comparison with normolipidemic groups. No correlation of these indexes with serum levels of triacylglycerides was detectable. The authors come to a conclusion that type IV HLP in patients with psoriasis is of a multifactorial origin and that sex-associated differences characteristic of hypertriacylglyceridemia may be explained by the specific influence of male and female hormones on lipoprotein metabolism.
对泛发性寻常型银屑病患者的检查结果表明，与血脂正常的患者相比，IV型高脂蛋白血症（HLP）女性患者的高密度脂蛋白（HDLP）胆固醇降低，男性患者的低密度脂蛋白胆固醇降低。仅在接受降脂和细胞抑制药物治疗的IV型HLP男性患者中发现血清甘油三酯与HDLP胆固醇浓度之间存在相关性（r = -0.72，p < 0.01）。与血脂正常组相比，这些患者的住院时间更长，缓解次数更少。未检测到这些指标与血清甘油三酯水平之间的相关性。作者得出结论，银屑病患者的IV型HLP具有多因素起源，高甘油三酯血症的性别相关差异可能由男性和女性激素对脂蛋白代谢的特定影响来解释。
