孕期使用抗抑郁药物：在信息的海洋中航行。
Antidepressant use during pregnancy: navigating the sea of information.
出版信息
Can Fam Physician. 2013 Sep;59(9):941, 943-4.
QUESTION
When some of my patients who are taking antidepressants learn they are pregnant, they become anxious and confront me with the following statement: "I need this medication, but have heard so many conflicting stories from my friends and on the Internet and in the media that I am not sure if I should continue taking it." How do I advise them, as I have also seen conflicting evidence in the scientific literature?
ANSWER
To date, antidepressants are the most studied drugs during pregnancy, with more than 30 000 outcomes examining increased risks of adverse effects on exposed infants. The results of the studies can appear to be conflicting owing to differing interpretation of statistical analysis and subsequent knowledge transfer and translation of the information. However, there does not appear to be a clinically significant increased risk of any of the adverse outcomes reported in peer-reviewed published studies that would preclude a woman from taking a needed antidepressant during pregnancy.
问题
当我的一些正在服用抗抑郁药的患者得知自己怀孕时，他们会变得焦虑，并对我说：“我需要这种药物，但从我的朋友、互联网和媒体上听到了很多相互矛盾的说法，我不确定是否应该继续服用。”我应该如何为他们提供建议，因为我在科学文献中也看到了相互矛盾的证据？
答案
迄今为止，抗抑郁药是在怀孕期间研究最多的药物，有超过 30000 例结果研究了暴露于这些药物的婴儿出现不良反应的风险增加。研究结果可能会出现相互矛盾的情况，这是由于对统计分析的不同解释，以及随后对信息的知识转移和翻译。然而，在经过同行评议的已发表研究中，并没有出现任何被报道的不良后果有临床意义的风险增加，这使得女性在怀孕期间无法服用所需的抗抑郁药。
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