[（18）F-FDG PET/CT与传统检查方法对乳腺癌患者治疗后复发和转移检测的对比研究]
[The compared study in detecting the recurrence and metastases of breast cancer patients post treatment between (18)F-FDG PET/CT and conventional workup].
作者信息
Zhang Wei-guang, Wang Guo-hui, Zhang Wei-dong, Fan Wei, Li Jian
机构信息
Department of Nuclear Medicine, Sun Yat-sen University, Guangzhou, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2013 May 21;93(19):1446-9.
OBJECTIVE
This study is to investigate the clinical role of (18)F-FDG PET/CT in detecting the recurrence and metastases of patients with breast cancer post treatment, compared to the conventional imaging technology, such as CT, MRI, and ultrasound.
METHODS
The reports of FDG PET/CT whole body scans and conventional imaging technology, such as CT, MRI, and ultrasound, performed from Jan to Aug 2011 on 70 patients with breast cancer post treatment were retrospectively reviewed.The accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 2 groups in detecting the recurrence and metastases were calculated and compared.
RESULTS
The accuracy, sensitivity, specificity, PPV and NPV of FDG PET/CT were 84.3%, 95.6%, 64.0%, 82.7% and 88.9%.The conventional imaging technology was 70.0%, 68.9%, 72.0%, 81.6% and 56.3% respectively.FDG PET/CT had altered the medical management of 20% of patients and detected 3 second primary malignancies.
CONCLUSION
FDG PET/CT is superior to conventional imaging in detecting the recurrence and metastases of patients with breast cancer post therapy.
目的
本研究旨在探讨（18）F-FDG PET/CT在检测乳腺癌治疗后患者复发和转移方面的临床作用，并与CT、MRI和超声等传统成像技术进行比较。
方法
回顾性分析2011年1月至8月对70例乳腺癌治疗后患者进行的FDG PET/CT全身扫描以及CT、MRI和超声等传统成像技术的报告。计算并比较两组在检测复发和转移方面的准确性、敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。
结果
FDG PET/CT的准确性、敏感性、特异性、PPV和NPV分别为84.3%、95.6%、64.0%、82.7%和88.9%。传统成像技术分别为70.0%、68.9%、72.0%、81.6%和56.3%。FDG PET/CT改变了20%患者的治疗方案，并检测出3例第二原发性恶性肿瘤。
结论
在检测乳腺癌治疗后患者的复发和转移方面，FDG PET/CT优于传统成像技术。
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