Department of Nuclear Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea.
Phys Med Biol. 2013 Oct 7;58(19):6985-7007. doi: 10.1088/0031-9155/58/19/6985. Epub 2013 Sep 13.
The International Commission on Radiological Protection (ICRP) reference phantoms, developed based on computed tomography images of human bodies, provide much more realism of human anatomy than the previously used MIRD5 (Medical Internal Radiation Dose) mathematical phantoms. It has been, however, realized that the ICRP reference phantoms have some critical limitations showing a considerable amount of holes for the skin and wall organs mainly due to the nature of voxels of which the phantoms are made, especially due to their low voxel resolutions. To address this problem, we are planning to develop the polygon-surface version of ICRP reference phantoms by directly converting the ICRP reference phantoms (voxel phantoms) to polygon-surface phantoms. The objective of this preliminary study is to see if it is indeed possible to construct the high-quality polygon-surface phantoms based on the ICRP reference phantoms maintaining identical organ morphology and also to identify any potential issues, and technologies to address these issues, in advance. For this purpose, in the present study, the ICRP reference male phantom was roughly converted to a polygon-surface phantom. Then, the constructed phantom was implemented in Geant4, Monte Carlo particle transport code, for dose calculations, and the calculated dose values were compared with those of the original ICRP reference phantom to see how much the calculated dose values are sensitive to the accuracy of the conversion process. The results of the present study show that it is certainly possible to convert the ICRP reference phantoms to surface phantoms with enough accuracy. In spite of using relatively less resources (<2 man-months), we were able to construct the polygon-surface phantom with the organ masses perfectly matching the ICRP reference values. The analysis of the calculated dose values also implies that the dose values are indeed not very sensitive to the detailed morphology of the organ models in the phantom for highly penetrating radiations such as photons and neutrons. The results of the electron beams, on the other hand, show that the dose values of the polygon-surface phantom are higher by a factor of 2-5 times than those of the ICRP reference phantom for the skin and wall organs which have large holes due to low voxel resolution. The results demonstrate that the ICRP reference phantom could provide significantly unreasonable dose values to thin or wall organs especially for weakly penetrating radiations. Therefore, when compared to the original ICRP reference phantoms, it is believed that the polygon-surface version of ICRP reference phantoms properly developed will not only provide the same or similar dose values (say, difference <5 or 10%) for highly penetrating radiations, but also provide correct dose values for the weakly penetrating radiations such as electrons and other charged particles.
国际辐射防护委员会(ICRP)参考人体模型是基于人体的计算机断层扫描图像开发的,与之前使用的 MIRD5(医学内部辐射剂量)数学模型相比,它更能真实地反映人体解剖结构。然而,已经意识到 ICRP 参考人体模型存在一些关键限制,其皮肤和壁组织器官存在大量空洞,这主要是由于构成模型的体素的性质造成的,特别是由于其体素分辨率低。为了解决这个问题,我们计划通过直接将 ICRP 参考人体模型(体素模型)转换为多边形表面模型来开发 ICRP 参考人体模型的多边形表面版本。本初步研究的目的是确定是否可以基于 ICRP 参考人体模型构建高质量的多边形表面人体模型,同时保持相同的器官形态,并且提前发现任何潜在的问题和解决这些问题的技术。为此,在本研究中,我们将 ICRP 参考男性人体模型粗略地转换为多边形表面模型。然后,将构建的模型在 Geant4 蒙特卡罗粒子输运代码中实现,以进行剂量计算,并将计算出的剂量值与原始 ICRP 参考模型进行比较,以了解计算出的剂量值对转换过程的准确性有多敏感。本研究的结果表明,将 ICRP 参考人体模型转换为具有足够精度的表面模型是完全可行的。尽管使用的资源相对较少(<2 人月),但我们还是能够构建器官质量与 ICRP 参考值完全匹配的多边形表面模型。对计算出的剂量值的分析也表明,对于光子和中子等高穿透力辐射,器官模型的详细形态对剂量值的影响确实不大。另一方面,对于电子束,结果表明,由于体素分辨率低,多边形表面模型的皮肤和壁组织器官的剂量值比 ICRP 参考模型高 2-5 倍。结果表明,对于较薄的器官或壁组织,特别是对于穿透力较弱的辐射,ICRP 参考人体模型可能会提供非常不合理的剂量值。因此,与原始的 ICRP 参考人体模型相比,相信适当开发的 ICRP 参考人体模型的多边形表面版本不仅会为高穿透力辐射提供相同或相似的剂量值(例如,差异<5 或 10%),而且还会为电子和其他带电粒子等穿透力较弱的辐射提供正确的剂量值。