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口服对比剂增强活体 NIS 报告基因成像的分辨率。

Oral contrast enhances the resolution of in-life NIS reporter gene imaging.

机构信息

Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.

出版信息

Cancer Gene Ther. 2013 Nov;20(11):638-41. doi: 10.1038/cgt.2013.57. Epub 2013 Sep 13.

DOI:10.1038/cgt.2013.57
PMID:24030210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3867790/
Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

摘要

碘钠同向转运体（NIS）报告基因成像是一种用于活体动物中无创性细胞命运检测的优秀技术，除非 NIS 转导细胞位于胃周围器官中，如脾脏、肝脏、膈肌、大网膜、胰腺、胃周淋巴结或胃周肿瘤沉积物。在这里，我们报告口服硫酸钡可增强 CT 对胃的定义，遮蔽胃的背景伽马射线发射，并增强放射性示踪剂摄取的 NIS 转导器官中的信号检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fd/3867790/afd3fdb528b7/nihms515165f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fd/3867790/5fc7b1ecf03d/nihms515165f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fd/3867790/afd3fdb528b7/nihms515165f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fd/3867790/5fc7b1ecf03d/nihms515165f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fd/3867790/afd3fdb528b7/nihms515165f2.jpg

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