Takahashi R, Yamaguchi K, Tamai M
Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
Nippon Ganka Gakkai Zasshi. 1990 Jun;94(6):593-6.
Immunosuppressive acidic protein (IAP) is a useful tumor marker for evaluating clinical course, therapeutic effectiveness, and prognosis of patients with various malignant tumors. In this report, we examined the serum IAP levels in 20 patients with retinoblastomas. In 6 cases, both preoperative and postoperative IAP values were examined, and in 14 cases the levels of this protein were postoperatively followed. Although 2 of 6 cases had higher levels of IAP than 500 micrograms/ml preoperatively, they had decreased within the normal range (less than 500 micrograms/ml) postoperatively. The mean IAP levels at 1-2 weeks before, 1-2 weeks after and 1 month after surgery were 422 +/- 225.1 micrograms/ml, 221 +/- 62.6 micrograms/ml, and 297 +/- 89.8 micrograms/ml, respectively, that means IAP decreased after enucleation. In 14 cases in which this protein was examined only postoperatively the value was 314.5 +/- 91.6 micrograms/ml. In one case with a level of 856 micrograms/ml of IAP before enucleation, pathological examination revealed invasion of retinoblastoma cells to the optic nerve and orbital fat. The high level of IAP might be related to the extraocular invasion. Since the level of serum IAP decreased after enucleation, these results suggested that immunological activities might change, even though tumor cells grew within the blood retinal barrier.
免疫抑制酸性蛋白（IAP）是评估各种恶性肿瘤患者临床病程、治疗效果及预后的一种有用的肿瘤标志物。在本报告中，我们检测了20例视网膜母细胞瘤患者的血清IAP水平。其中6例患者术前和术后均检测了IAP值，14例患者术后对该蛋白水平进行了随访。虽然6例中有2例术前IAP水平高于500微克/毫升，但术后降至正常范围（低于500微克/毫升）。手术前1 - 2周、手术后1 - 2周和1个月时的平均IAP水平分别为422±225.1微克/毫升、221±62.6微克/毫升和297±89.8微克/毫升，这表明眼球摘除术后IAP降低。在仅术后检测该蛋白的14例患者中，其值为314.5±91.6微克/毫升。在1例眼球摘除术前IAP水平为856微克/毫升的患者中，病理检查显示视网膜母细胞瘤细胞侵犯视神经和眶脂肪。IAP水平高可能与眼外侵犯有关。由于眼球摘除术后血清IAP水平降低，这些结果提示即使肿瘤细胞在血视网膜屏障内生长，免疫活性可能也会发生变化。
