Fisher J, Ingham E, Stone M H
Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds - UK.
Hip Int. 2003 Mar 15;13(1):31-5. doi: 10.1177/112070000301302s07.
;There is now considerable clinical concern about the effect of polyethylene wear debris induced osteolysis in long term failure of hip replacements. This paper compares the wear of stabilised and crosslinked polyethylene to alternative hard on hard bearings. The volumetric wear rates of stabilised and moderately crosslinked polyethylene 50 to 35 mm/million cycles were less than previously reported for historical gamma irradiated in air polyethylene, but still of a level that in the long term could cause osteolysis. The moderately crosslinked polyethylene produced less wear than non-crosslinked polyethylene, but particles were smaller and more reactive resulting in little change in the osteolytic potential. Alumina ceramic on ceramic produced substantially less wear and osteolytic potential. Metal on metal also produced less wear than polyethylene but the particles adversely influence cell viability.
目前,临床对聚乙烯磨损颗粒诱发的骨溶解在髋关节置换长期失败中所起的作用极为关注。本文比较了稳定型和交联聚乙烯与其他硬对硬轴承的磨损情况。稳定型和适度交联聚乙烯的体积磨损率为50至35立方毫米/百万次循环,低于以往报道的空气中γ辐照聚乙烯的磨损率,但从长期来看仍处于可能导致骨溶解的水平。适度交联聚乙烯的磨损比未交联聚乙烯少,但颗粒更小且更具反应性,导致溶骨潜能变化不大。氧化铝陶瓷对陶瓷的磨损和溶骨潜能显著更低。金属对金属的磨损也比聚乙烯少,但颗粒会对细胞活力产生不利影响。