Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada; Division of Endocrinology, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Quebec, Canada; Centre de Recherche du CHU Sainte Justine, Montréal, Quebec, Canada.
Obesity (Silver Spring). 2014 Feb;22(2):504-11. doi: 10.1002/oby.20619. Epub 2013 Oct 16.
To determine the independent associations of moderate to vigorous physical activity (MVPA), fitness, screen time, and adiposity with insulin secretion in children.
Caucasian youth (n = 423/630), 8-10 years old, with at least one obese biological parent, were studied (QUALITY cohort). Insulin secretion was measured using HOMA2-%B, area under the curve (AUC) of insulin to glucose over the first 30 minutes (AUC I/G(t30min)) of the OGTT and AUC I/G(t120min) over 2 hours. Fitness was measured by VO₂peak ; percent fat mass (PFM) by DXA; 7-day MVPA by accelerometry; self-reported screen time included television, video game, or computer use. Models were adjusted for age, sex, season, puberty, PFM, and insulin sensitivity [IS] (HOMA2-IS, Matsuda-ISI).
PFM was strongly associated with insulin secretion, even after adjustment for IS: for every 1% increase in PFM, insulin secretion increased from 0.3% to 0.8% across indices. MVPA was negatively associated with HOMA2-%B (P < 0.05), but not with OGTT-derived measures. Fitness was negatively associated with AUC I/G(t120min) (P < 0.05). Screen time showed a trend toward higher HOMA2-%B in girls (P = 0.060).
In children with an obese parent, lower insulin secretion is associated with lower adiposity, higher MVPA, better fitness, and possibly reduced screen time.
确定中高强度体力活动（MVPA）、体能、屏幕时间和肥胖与儿童胰岛素分泌的独立相关性。
对至少有一位肥胖亲生父母的白种人青少年（n=423/630）进行了研究（QUALITY 队列）。使用 HOMA2-%B、OGTT 前 30 分钟胰岛素与血糖的曲线下面积（AUC I/G(t30min))和 2 小时内 AUC I/G(t120min)测量胰岛素分泌。VO₂peak 测量体能；DXA 测量体脂肪百分比（PFM）；加速度计测量 7 天 MVPA；自我报告的屏幕时间包括电视、视频游戏或计算机使用时间。模型调整了年龄、性别、季节、青春期、PFM 和胰岛素敏感性[HOMA2-IS、Matsuda-ISI]。
即使在调整了胰岛素敏感性后，PFM 与胰岛素分泌也有很强的相关性：PFM 每增加 1%，各指数的胰岛素分泌增加 0.3%至 0.8%。MVPA 与 HOMA2-%B 呈负相关（P<0.05），但与 OGTT 衍生指标无关。体能与 AUC I/G(t120min)呈负相关（P<0.05）。屏幕时间显示女孩的 HOMA2-%B 呈升高趋势（P=0.060）。
在有肥胖父母的儿童中，较低的胰岛素分泌与较低的肥胖率、较高的 MVPA、较好的体能和可能减少的屏幕时间相关。
