中国 e 抗原阴性乙型肝炎病毒感染者中前核心区 G1896A 突变的流行情况及其与 pre-S1 抗原的关系。
Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen.
机构信息
Department of Clinical Laboratory, Dalian Central Hospital, Dalian 116033 , Liaoning Province , China.
出版信息
Braz J Microbiol. 2009 Oct;40(4):965-71. doi: 10.1590/S1517-838220090004000031. Epub 2009 Dec 1.
Abstract
This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients.
摘要
本研究调查了中国乙型肝炎 e 抗原 (HBeAg) 阴性 HBV 感染者中前核心 G1896A 突变的流行情况及其与血清 HBV pre-S1 抗原的关系。在 HBeAg 阴性、血清 HBV DNA 可检测的中国患者中，前核心 G1896A 突变的总流行率为 72.6%。前核心 G1896A 在中国 HBeAg 阴性慢性乙型肝炎患者中的流行率明显高于血清 HBV DNA 可检测的非活动 HBV 携带者。大多数中国 HBeAg 阴性患者同时检测到血清 pre-S1 和前核心 G1896A 突变。
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