van Wyk I Conradie, Goddard A, de C Bronsvoort B M, Coetzer J A W, Booth C, Hanotte O, Jennings A, Kiara H, Mashego P, Muller C, Pretorius G, Poole E J, Thumbi S M, Toye P G, Woolhouse M E J, Penzhorn B L
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X4, Onderstepoort, Pretoria, 0110 South Africa.
Comp Clin Path. 2012 Jun 1;22(5):1029-1036. doi: 10.1007/s00580-012-1522-6. eCollection 2012.
This paper is the first attempt to accurately describe the hematological parameters for any African breed of cattle, by capturing the changes in these parameters over the first 12 months of an animal's life using a population-based sample of calves reared under field conditions and natural disease challenge. Using a longitudinal study design, a stratified clustered random sample of newborn calves was recruited into the IDEAL study and monitored at 5-weekly intervals until 51 weeks of age. The blood cell analysis performed at each visit included: packed cell volume; red cell count; red cell distribution width; mean corpuscular volume; mean corpuscular hemoglobin concentration; hemoglobin concentration; white cell count; absolute lymphocyte, eosinophil, monocyte, and neutrophil counts; platelet count; mean platelet volume; and total serum protein. The most significant age-related change in the red cell parameters was a rise in red cell count and hemoglobin concentration during the neonatal period. This is in contrast to what is reported for other ruminants, including European cattle breeds where the neonatal period is marked by a fall in the red cell parameters. There is a need to establish breed-specific reference ranges for blood parameters for indigenous cattle breeds. The possible role of the postnatal rise in the red cell parameters in the adaptability to environmental constraints and innate disease resistance warrants further research into the dynamics of blood cell parameters of these breeds.
本文首次尝试准确描述任何非洲牛品种的血液学参数，通过在野外条件和自然疾病挑战下饲养的小牛群体样本，捕捉动物生命最初12个月内这些参数的变化。采用纵向研究设计，将分层整群随机抽取的新生小牛纳入理想研究，并每隔5周进行监测，直至51周龄。每次访视时进行的血细胞分析包括：红细胞压积；红细胞计数；红细胞分布宽度；平均红细胞体积；平均红细胞血红蛋白浓度；血红蛋白浓度；白细胞计数；绝对淋巴细胞、嗜酸性粒细胞、单核细胞和中性粒细胞计数；血小板计数；平均血小板体积；以及总血清蛋白。红细胞参数中与年龄最相关的显著变化是新生儿期红细胞计数和血红蛋白浓度升高。这与其他反刍动物的报道相反，包括欧洲牛品种，其新生儿期的特征是红细胞参数下降。有必要为本土牛品种建立血液参数的品种特异性参考范围。出生后红细胞参数升高在适应环境限制和先天抗病性方面的可能作用，值得进一步研究这些品种血细胞参数的动态变化。
