Division of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Nutr Rev. 2013 Sep;71(9):600-10. doi: 10.1111/nure.12043. Epub 2013 Jul 10.
Osteoporosis is a disease characterized by low bone mass and the structural deterioration of bone tissue. It is estimated that 44 million Americans and 55% of those over 50 years of age are currently affected by this disease. Among other risk factors for osteoporotic fracture, dietary fat in general and essential fatty acids (EFA) in particular have recently been investigated because of their suspected impact on the bone remodeling process. This article reviews the growing body of literature concerning EFA and bone health. In particular, two recent large prospective cohort studies evaluating the association between multiple types of EFA and risk of osteoporotic fracture are highlighted. The results of these studies are placed in context with the existing literature, and recommendations for future investigation are presented.
骨质疏松症是一种以骨量低和骨组织结构退化为特征的疾病。据估计，目前有 4400 万美国人，55%的 50 岁以上的人患有这种疾病。在骨质疏松性骨折的其他危险因素中，膳食脂肪，特别是必需脂肪酸（EFA），最近因其对骨重塑过程的可疑影响而受到研究。本文综述了关于 EFA 和骨骼健康的不断增加的文献。特别是，重点介绍了两项最近评估多种 EFA 类型与骨质疏松性骨折风险之间关系的大型前瞻性队列研究。将这些研究的结果与现有文献联系起来，并提出了未来研究的建议。
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