Lupsa Beatrice C, Insogna Karl
Department of Internal Medicine, Yale Bone Center, Yale University School of Medicine, New Haven, CT, USA.
Department of Internal Medicine, Yale Bone Center, Yale University School of Medicine, New Haven, CT, USA.
Endocrinol Metab Clin North Am. 2015 Sep;44(3):517-30. doi: 10.1016/j.ecl.2015.05.002.
Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to decreased bone strength and an increased risk of low-energy fractures. Central dual-energy X-ray absorptiometry measurements are the gold standard for determining bone mineral density. Bone loss is an inevitable consequence of the decrease in estrogen levels during and following menopause, but additional risk factors for bone loss can also contribute to osteoporosis in older women. A well-balanced diet, exercise, and smoking cessation are key to maintaining bone health as women age. Pharmacologic agents should be recommended in patients at high risk for fracture.
骨质疏松症的特征是骨量低和骨组织微结构恶化,导致骨强度下降以及低能量骨折风险增加。中心双能X线吸收测定法是确定骨密度的金标准。骨质流失是绝经期间及绝经后雌激素水平下降的必然结果,但骨质流失的其他风险因素也可能导致老年女性患骨质疏松症。随着女性年龄增长,均衡饮食、运动和戒烟是维持骨骼健康的关键。对于骨折高危患者,应推荐使用药物治疗。