Boynosky N A, Stokking L B
Department of Dermatology, Veterinary Specialty Hospital, San Diego, CA, 92121, USA.
J Small Anim Pract. 2014 Dec;55(12):640-2. doi: 10.1111/jsap.12129. Epub 2013 Sep 6.
Two cases of panniculitis associated with administration of potassium bromide in dogs are reported. Both dogs were treated with potassium bromide for idiopathic epilepsy for over 1 year. Dose increases in both cases were associated with panniculitis, characterised by painful subcutaneous nodules in a generalised distribution over the trunk. Nodule eruption waxed and waned in one dog and was persistent in the other. In both cases, panniculitis was accompanied by lethargy and pyrexia. Panniculitis, lethargy and pyrexia resolved and failed to recur after discontinuation of potassium bromide. No other cause of panniculitis could be determined for either dog. Panniculitis has been reported after administration of potassium bromide in humans and may be a form of drug-induced erythema nodosum. To the authors' knowledge, these are the first reports of potassium bromide-associated panniculitis in dogs.
本文报告了两例犬溴化钾给药后相关的脂膜炎病例。两只犬均因特发性癫痫接受溴化钾治疗超过1年。两例病例中，剂量增加均与脂膜炎相关，其特征为躯干广泛分布的疼痛性皮下结节。一只犬的结节皮疹有消长变化，另一只犬则持续存在。两例病例中，脂膜炎均伴有嗜睡和发热。停用溴化钾后，脂膜炎、嗜睡和发热症状均消退且未复发。两只犬均未发现其他脂膜炎病因。人类服用溴化钾后也曾报告过脂膜炎，可能是药物性结节性红斑的一种形式。据作者所知，这是犬溴化钾相关脂膜炎的首例报告。
