Atmaca Murad
Firat (Euphrates) Universitesi, Firat Tip Merkezi, Psikiyatri Anabilim Dali, 23119 Elazig, Turkey.
Rev Recent Clin Trials. 2013 Jun;8(2):124-7. doi: 10.2174/15748871113086660050.
In the present article, structural, neurochemical and functional neuroimaging investigations performed on patients with social anxiety disorder were reviewed. A PubMed search was performed to identify all structural and functional neuroimaging studies published between 1980 and February 2013. The studies and case reports on neuroimaging in social anxiety disorder were grouped under the subheadings of structural, functional and magnetic resonance spectroscopic imaging. It seems that structural studies involve examination of abnormalities in the basal ganglia structures like caudate nucleus, thalamus, and putamen, hippocampus and amygdala abnormalities in summary. Neurochemical investigations reveal the deficiencies in the GABAergic system and over-activation in the glutamatergic system in social anxiety disorder. Functional neuroimaging investigations implicate the role of limbic-medial prefrontal circuit.
在本文中，我们综述了对社交焦虑障碍患者进行的结构、神经化学和功能神经影像学研究。通过PubMed检索，以确定1980年至2013年2月期间发表的所有结构和功能神经影像学研究。关于社交焦虑障碍神经影像学的研究和病例报告分为结构、功能和磁共振波谱成像三个副标题。结构研究似乎涉及对基底神经节结构（如尾状核、丘脑和壳核）异常的检查，以及海马体和杏仁核的异常。神经化学研究表明，社交焦虑障碍患者存在γ-氨基丁酸能系统缺陷和谷氨酸能系统过度激活。功能神经影像学研究表明边缘-内侧前额叶回路发挥了作用。
