Rashid Aneeqa, Khan Umar Ali
Department of Physiology, Islamic International Medical College, Rawalpindi.
J Coll Physicians Surg Pak. 2013 Sep;23(9):649-52.
To determine the effect of ascorbic acid supplementation on long-term cold exposure induced changes in thyroid activity in Sprague-Dawley rats.
Experimental study.
Physiology Department of Islamic International Medical College, Rawalpindi, National Institute of Health, Islamabad and Railway Hospital, Rawalpindi, from January to December 2009.
Ninety Sprague-Dawley rats were randomly divided into three groups of control, cold exposed and cold exposed along with ascorbic acid supplementation. After one month, their thyroid levels were analyzed by using chemiluminescent immunometric assay on Siemens Immulite 2000 Analyzer.
After 4 weeks of cold exposure to experimental animals, the thyroid activity was raised significantly in the cold exposed group as compared to the control group (p-value for T3 difference = 0.004, T4 difference = 0.002 and TSH difference < 0.001). Supplementation with ascorbic acid in the third group normalized the thyroid hormone activity with p-value for difference in levels of T3 being 0.6661, T4 = 0.027 and TSH = 0.0028.
Ascorbic acid prevented the cold induced changes in thyroid hormone levels in rodents.
确定补充抗坏血酸对长期冷暴露诱导的斯普拉格-道利大鼠甲状腺活动变化的影响。
实验研究。
2009年1月至12月，位于拉瓦尔品第的伊斯兰国际医学院生理学系、伊斯兰堡的国家卫生研究所和拉瓦尔品第的铁路医院。
将90只斯普拉格-道利大鼠随机分为三组：对照组、冷暴露组和冷暴露并补充抗坏血酸组。1个月后，使用西门子Immulite 2000分析仪通过化学发光免疫分析法分析它们的甲状腺水平。
对实验动物进行4周冷暴露后，与对照组相比，冷暴露组的甲状腺活动显著升高（T3差异的p值=0.004，T4差异=0.002，TSH差异<0.001）。第三组补充抗坏血酸使甲状腺激素活性恢复正常，T3水平差异的p值为0.6661，T4 = 0.027，TSH = 0.0028。
抗坏血酸可预防啮齿动物因寒冷引起的甲状腺激素水平变化。
