宿主遗传学在流感易感性中的作用的更新系统评价。
An updated systematic review of the role of host genetics in susceptibility to influenza.
机构信息
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Vietnam.
The Roslin Institute, University of Edinburgh, Edinburgh, UK.
出版信息
Influenza Other Respir Viruses. 2013 Sep;7 Suppl 2(Suppl 2):37-41. doi: 10.1111/irv.12079.
The World Health Organization has identified studies of the role of host genetics on susceptibility to severe influenza as a priority. A systematic review was conducted in June 2011 to summarise the evidence on the role of host genetics in susceptibility to influenza, and this report updates that previously published review. Animal studies suggest that genetic control of susceptibility to severe influenza in mice is complex and not controlled by a single locus, but there is encouraging evidence that some of the host genetic determinants of susceptibility to severe disease may be common across influenza subtypes. Although a number of studies on genetic susceptibility to influenza in humans have been published recently, all are underpowered and unreplicated, so do not provide robust statistical evidence of an association between the identified genetic loci and susceptibility. One study does however present convincing functional evidence for an important role for IFITM3 in susceptibility to severe influenza in mice, and some evidence that this may also be important in human A/H1N1/pdm2009 infection.
世界卫生组织已经确定了宿主遗传学在严重流感易感性中的作用研究是优先事项。2011 年 6 月进行了系统评价，以总结宿主遗传学在流感易感性中的作用的证据，本报告更新了之前发表的综述。动物研究表明，宿主对严重流感易感性的遗传控制在小鼠中是复杂的，不受单个基因座控制，但有令人鼓舞的证据表明，严重疾病易感性的一些宿主遗传决定因素可能在流感亚型之间是共同的。尽管最近已经发表了一些关于人类对流感遗传易感性的研究，但所有这些研究都没有足够的效力且没有重复，因此不能提供与所确定的遗传基因座和易感性之间存在关联的强有力的统计证据。然而，有一项研究确实提供了令人信服的功能证据，表明 IFITM3 在小鼠严重流感易感性中起着重要作用，并且有一些证据表明，这在人类 A/H1N1/pdm2009 感染中也很重要。
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