University of Colorado Denver School of Medicine, Department of Obstetrics and Gynecology, 12631 E. 17th Avenue, Academic Office 1, Room 4006, Aurora, CO 80045.
Contraception. 2013 Dec;88(6):712-6. doi: 10.1016/j.contraception.2013.08.001. Epub 2013 Aug 8.
Induction of fetal demise via transabdominal injection has been used to facilitate second-trimester abortion but requires a second procedure and has associated risks. The method of amniotomy, cord transection and documentation of fetal asystole immediately prior to dilation and evacuation (D&E) is an alternative approach; however, characteristics of this method have not been described.
This descriptive report from a single center involves a large case series of D&Es ranging from 16 to 23 weeks of gestation. Umbilical cord transection (UCT) was attempted immediately prior to D&E in 407 cases, which were reviewed to determine success, time to fetal asystole and complications.
Both UCT and asystole were achieved in 100% of cases. Mean time from UCT to asystole was 3.35±2.11 min. When compared to cases performed at less than 20 weeks of gestation, mean time to asystole was slightly longer in the ≥20-week group (3.7±2.4 min vs. 3.1±1.9 min; p=.008). Few patients had minor (4.6%) or major (0.3%) complications; time to asystole was not associated with complications.
Umbilical cord transection immediately prior to D&E is a feasible, efficacious and safe way to induce fetal demise without performing additional procedures.
This study demonstrates the feasibility, effectiveness and safety of utilizing umbilical cord transection to induce fetal demise in a large cohort. This method is an alternative to other feticidal procedures.
经腹注射诱导胎儿死亡已被用于促进中期流产,但需要进行第二次手术,并且存在相关风险。在扩张和排空(D&E)之前进行羊膜穿刺术、脐带切断和记录胎儿停搏的方法是一种替代方法;然而,这种方法的特点尚未描述。
这项来自单一中心的描述性报告涉及范围广泛的 D&E 病例系列,妊娠 16 至 23 周不等。在 407 例病例中,在 D&E 之前尝试进行脐带切断(UCT),对这些病例进行了回顾,以确定成功率、胎儿停搏时间和并发症。
UCT 和停搏在 100%的病例中均实现。从 UCT 到停搏的平均时间为 3.35±2.11 分钟。与妊娠 20 周以下的病例相比,≥20 周组的平均停搏时间稍长(3.7±2.4 分钟比 3.1±1.9 分钟;p=.008)。少数患者出现轻微(4.6%)或严重(0.3%)并发症;停搏时间与并发症无关。
在 D&E 之前进行脐带切断是一种可行、有效且安全的方法,可以在不进行其他手术的情况下诱导胎儿死亡。
本研究在一个大队列中证明了利用脐带切断诱导胎儿死亡的可行性、有效性和安全性。这种方法是其他杀胎手术的替代方法。