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在孕中期 D&E 流产前通过切断脐带诱导胎儿死亡。

Umbilical cord transection to induce fetal demise prior to second-trimester D&E abortion.

机构信息

University of Colorado Denver School of Medicine, Department of Obstetrics and Gynecology, 12631 E. 17th Avenue, Academic Office 1, Room 4006, Aurora, CO 80045.

出版信息

Contraception. 2013 Dec;88(6):712-6. doi: 10.1016/j.contraception.2013.08.001. Epub 2013 Aug 8.

Abstract

OBJECTIVE

Induction of fetal demise via transabdominal injection has been used to facilitate second-trimester abortion but requires a second procedure and has associated risks. The method of amniotomy, cord transection and documentation of fetal asystole immediately prior to dilation and evacuation (D&E) is an alternative approach; however, characteristics of this method have not been described.

STUDY DESIGN

This descriptive report from a single center involves a large case series of D&Es ranging from 16 to 23 weeks of gestation. Umbilical cord transection (UCT) was attempted immediately prior to D&E in 407 cases, which were reviewed to determine success, time to fetal asystole and complications.

RESULTS

Both UCT and asystole were achieved in 100% of cases. Mean time from UCT to asystole was 3.35±2.11 min. When compared to cases performed at less than 20 weeks of gestation, mean time to asystole was slightly longer in the ≥20-week group (3.7±2.4 min vs. 3.1±1.9 min; p=.008). Few patients had minor (4.6%) or major (0.3%) complications; time to asystole was not associated with complications.

CONCLUSIONS

Umbilical cord transection immediately prior to D&E is a feasible, efficacious and safe way to induce fetal demise without performing additional procedures.

IMPLICATION STATEMENT

This study demonstrates the feasibility, effectiveness and safety of utilizing umbilical cord transection to induce fetal demise in a large cohort. This method is an alternative to other feticidal procedures.

摘要

目的

经腹注射诱导胎儿死亡已被用于促进中期流产,但需要进行第二次手术,并且存在相关风险。在扩张和排空(D&E)之前进行羊膜穿刺术、脐带切断和记录胎儿停搏的方法是一种替代方法;然而,这种方法的特点尚未描述。

研究设计

这项来自单一中心的描述性报告涉及范围广泛的 D&E 病例系列,妊娠 16 至 23 周不等。在 407 例病例中,在 D&E 之前尝试进行脐带切断(UCT),对这些病例进行了回顾,以确定成功率、胎儿停搏时间和并发症。

结果

UCT 和停搏在 100%的病例中均实现。从 UCT 到停搏的平均时间为 3.35±2.11 分钟。与妊娠 20 周以下的病例相比,≥20 周组的平均停搏时间稍长(3.7±2.4 分钟比 3.1±1.9 分钟;p=.008)。少数患者出现轻微(4.6%)或严重(0.3%)并发症;停搏时间与并发症无关。

结论

在 D&E 之前进行脐带切断是一种可行、有效且安全的方法,可以在不进行其他手术的情况下诱导胎儿死亡。

意义

本研究在一个大队列中证明了利用脐带切断诱导胎儿死亡的可行性、有效性和安全性。这种方法是其他杀胎手术的替代方法。

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