泛素化对 TGF-β 信号的协调作用。
Coordination of TGF-β signaling by ubiquitylation.
机构信息
Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, 751 23 Uppsala, Sweden; Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 751 24 Uppsala, Sweden.
出版信息
Mol Cell. 2013 Sep 12;51(5):555-6. doi: 10.1016/j.molcel.2013.08.034.
PMID:24034692
Abstract
In this issue, Zhang et al. (2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells.
摘要
在本期中，Zhang 等人（2013 年）表明，泛素连接酶 TRAF4 与 TGF-β 受体结合，防止它们降解，并泛素化 TAK1 以激活非 Smad 信号通路，从而共同促进乳腺癌细胞的转移。
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