Department of Radiology, Charité - Universitätsmedizin Berlin, Charité Campus Mitte, Berlin, Germany.
Eur J Radiol. 2013 Dec;82(12):e749-54. doi: 10.1016/j.ejrad.2013.08.020. Epub 2013 Aug 24.
To evaluate specimen quality and diagnostic differences between magnetic resonance (MR) compatible 16 G and 18 G biopsy needles in MR-guided biopsy (MRGB) of the prostate.
Semiautomatic MR compatible biopsy needles with a diameter of 16 G (Group A) or 18 G (Group B) were used to perform MRGB in 88 patients with suspected prostate cancer. After embedding and staining, length and width of all specimens (140 cores in Group A, 143 in Group B) were measured. Fragmentation, squeezing artifacts, and overall evaluability were evaluated using a quality score from 0 (no tissue) to 3 (optimal tissue quality). Groups were statistically compared; p-values <0.05 were regarded as significant.
Demographic data were not significantly different between Group A and B with a mean age of 63 ± 7.3 and 67 ± 5.7 years; and a mean prostate-specific antigen of 12.6 ± 10.3 ng/ml and 13.8 ± 11.6 ng/ml, respectively (p=0.70). Area of longitudinally sectioned histological specimens was significantly larger in Group A than in Group B with 9.38 mm(2) (8.74; 10.02) and 7.95 mm(2) (7.32; 8.59), respectively (p=0.002). However, there were significantly more cores without prostate tissue with 18 cores (12.9%) versus 3 cores (2.1%) in Groups A and B, respectively (p=0.004). Fragmentation, squeezing artifacts, and overall evaluability were not statistically different between the two groups. The rate of prostate cancer in the cores was also not significantly different between Groups A and B (22.1% and 24.5%; p=0.77).
16 G biopsy needles do not provide a relevant diagnostic advantage over 18 G needles in MRGB. Therefore, use of 18 G needles is not discouraged and may even be preferred as it is not expected to result in a relevant degradation of specimen quality or compromise in prostate cancer detection rate.
评估磁共振（MR）兼容 16 G 和 18 G 活检针在 MR 引导下前列腺活检（MRGB）中的标本质量和诊断差异。
使用直径为 16 G（A 组）或 18 G（B 组）的半自动 MR 兼容活检针对 88 例疑似前列腺癌患者进行 MRGB。标本包埋和染色后，测量所有标本的长度和宽度（A 组 140 个核心，B 组 143 个核心）。使用 0（无组织）至 3（最佳组织质量）的质量评分评估碎裂、挤压伪影和整体可评估性。对两组进行统计学比较；p 值<0.05 视为有统计学意义。
A 组和 B 组的年龄、前列腺特异性抗原值无显著差异，平均年龄分别为 63±7.3 岁和 67±5.7 岁；平均前列腺特异性抗原值分别为 12.6±10.3ng/ml 和 13.8±11.6ng/ml（p=0.70）。A 组纵向切片组织标本的面积明显大于 B 组，分别为 9.38mm²（8.74；10.02）和 7.95mm²（7.32；8.59）（p=0.002）。然而，A 组无前列腺组织的核心明显更多，分别为 18 个（12.9%）和 3 个（2.1%）（p=0.004）。两组间碎裂、挤压伪影和整体可评估性无统计学差异。A 组和 B 组的核心前列腺癌检出率也无显著差异（分别为 22.1%和 24.5%；p=0.77）。
在 MRGB 中，16 G 活检针与 18 G 针相比没有提供明显的诊断优势。因此，不鼓励使用 18 G 针，甚至可能更倾向于使用 18 G 针，因为预计不会导致标本质量明显下降或前列腺癌检出率下降。
