骨髓中伴有 t(8;21)(q22;q22); RUNX1-RUNX1T1 的急性髓系白血病中骨髓肥大细胞的特征。
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
机构信息
Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, United States.
出版信息
Leuk Res. 2013 Nov;37(11):1572-5. doi: 10.1016/j.leukres.2013.08.010. Epub 2013 Sep 1.
Mast cells are often increased in AML with t(8;21). We analyzed characteristics of mast cells to elucidate their relationship with leukemic blasts. In 31 cases in which the results of KIT mutation analysis were available, five cases showed mutations. None of the cases positive for KIT mutation showed increased mast cells. In five cases with increased mast cells in which targeted-FISH analysis was performed for RUNX1-RUNX1T1, fusion signals demonstrated the translocation in mast cells in all cases. These findings confirm the shared origin between mast cells and leukemic blasts in AML with t(8;21).
肥大细胞在伴有 t(8;21)的 AML 中通常增加。我们分析了肥大细胞的特征，以阐明它们与白血病母细胞的关系。在 31 例可进行 KIT 突变分析的病例中，有 5 例存在突变。KIT 突变阳性的病例均无肥大细胞增多。在 5 例肥大细胞增多的病例中，对 RUNX1-RUNX1T1 进行了靶向 FISH 分析，所有病例的融合信号均显示出在肥大细胞中转位。这些发现证实了伴有 t(8;21)的 AML 中肥大细胞和白血病母细胞具有共同的起源。
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