Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Fertil Steril. 2013 Dec;100(6):1667-72. doi: 10.1016/j.fertnstert.2013.08.020. Epub 2013 Sep 12.
To determine the prevalence, course, and risk factors for nighttime hot flashes during the pregnancy and postpartum periods.
Clinical interview, physical measurements, and questionnaires administered at weeks 20, 30, and 36 of pregnancy and weeks 2, 12, 26, and 52 after delivery.
Academic medical setting.
PATIENT(S): 429 women.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Nighttime hot flashes.
RESULT(S): Thirty-five percent of women reported nighttime hot flashes during pregnancy and 29% after delivery. In multivariable binomial mixed effects models, women who were younger (per year: odds ratio [OR] 0.94; 95% confidence interval [CI], 0.88-0.99), had a higher prepregnancy body mass index (per unit increase: OR 1.05; 95% CI, 1.01-1.10), and had less than a college education (OR 2.58; 95% CI, 1.19-5.60; vs. ≥ college) were more likely to report nighttime hot flashes during pregnancy. Higher depressive symptoms were associated with nighttime hot flashes during pregnancy (per unit increase: OR 1.08; 95% CI, 1.04-1.13) and the postpartum period (OR 1.19; 95% CI, 1.14-1.25, multivariable models).
CONCLUSION(S): Hot flashes, typically considered a menopausal symptom, were reported by over a third of women during pregnancy and/or the postpartum period. The predictors of these hot flashes, including depressive symptoms, low education, and higher body mass index are similar to those experienced during menopause. Future work should investigate the role of hormonal and affective factors in hot flashes during pregnancy and postpartum.
确定孕期和产后夜间潮热的发生率、病程和危险因素。
临床访谈、身体测量和问卷调查，分别在孕期第 20、30 和 36 周以及产后第 2、12、26 和 52 周进行。
学术医疗环境。
429 名女性。
无。
夜间潮热。
35%的女性在孕期报告夜间潮热，29%的女性在产后报告夜间潮热。在多变量二项混合效应模型中，年龄较小（每年：比值比[OR]0.94；95%置信区间[CI]，0.88-0.99）、孕前体质量指数较高（每增加一个单位：OR 1.05；95%CI，1.01-1.10）和未接受过大学教育（OR 2.58；95%CI，1.19-5.60；与≥大学）的女性更有可能在孕期报告夜间潮热。较高的抑郁症状与孕期（每增加一个单位：OR 1.08；95%CI，1.04-1.13）和产后（OR 1.19；95%CI，1.14-1.25，多变量模型）的夜间潮热有关。
通常被认为是绝经期症状的潮热，有超过三分之一的女性在孕期和/或产后报告。这些潮热的预测因素，包括抑郁症状、低教育程度和较高的体质量指数，与绝经期经历的相似。未来的研究应探讨激素和情感因素在孕期和产后潮热中的作用。
