Mohamed Norazlina, Yin Chai Mei, Shuid Ahmad Nazrun, Muhammad Norliza, Babji Abdul Salam, Soelaiman Ima Nirwana
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan, Malaysia.
Pak J Pharm Sci. 2013 Sep;26(5):1027-31.
Cosmos caudatus (ulam raja) contains high mineral content and possesses high antioxidant activity which may be beneficial in bone disorder such as postmenopausal osteoporosis. The effects of C. caudatus on bone metabolism biomarkers in ovariectomized rats were studied. 48 Sprague-Dawley rats aged three months were divided into 6 groups. One group of rats was sham-operated while the remaining rats were ovariectomized. The ovariectomized rats were further divided into 5 groups: the control, three groups force-fed with C. caudatus at the doses of 100mg/kg, 200mg/kg or 300mg/kg and another group supplemented with calcium 1% ad libitum. Treatments were given 6 days per week for a period of eight weeks. Blood samples were collected twice; before and after treatment. Parameters measured were bone resorbing cytokine; interleukin-1 and the bone biomarkers; osteocalcin and pyridinoline. Serum IL-1 and pyridinoline levels were significantly increased in ovariectomized rats. Supplementation of C. caudatus was able to prevent the increase of IL-1 and pyridinoline in ovariectomized rats. Besides that, C. caudatus showed the same effect as calcium 1% on biochemical parameters of bone metabolism in ovariectomized rats. In conclusion, Cosmos caudatus was as effective as calcium in preventing the increase in bone resorption in ovariectomized rats.
红凤菜（ulam raja）含有高矿物质含量，并具有高抗氧化活性，这可能对诸如绝经后骨质疏松症等骨骼疾病有益。研究了红凤菜对去卵巢大鼠骨代谢生物标志物的影响。将48只3个月大的Sprague-Dawley大鼠分为6组。一组大鼠进行假手术，其余大鼠进行卵巢切除。将去卵巢大鼠进一步分为5组：对照组、三组分别以100mg/kg、200mg/kg或300mg/kg的剂量强制喂食红凤菜的组，以及另一组随意补充1%钙的组。每周进行6天治疗，为期8周。在治疗前后采集两次血样。测量的参数是骨吸收细胞因子白细胞介素-1和骨生物标志物骨钙素和吡啶啉。去卵巢大鼠的血清白细胞介素-1和吡啶啉水平显著升高。补充红凤菜能够防止去卵巢大鼠白细胞介素-1和吡啶啉的增加。除此之外，红凤菜在去卵巢大鼠骨代谢生化参数上显示出与1%钙相同的效果。总之，红凤菜在预防去卵巢大鼠骨吸收增加方面与钙一样有效。
