Camm A J, Paul V
Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom.
Am J Cardiol. 1990 Jan 2;65(2):67A-73A; discussion 82A-83A. doi: 10.1016/0002-9149(90)90206-g.
Used in adequate dosages, sotalol is efficacious in the conversion of acute supraventricular arrhythmias, an effect that is predictable on the basis of the drug's known electropharmacologic actions. Electrophysiologic studies have shown that both oral and intravenous sotalol are effective in preventing the induction of sustained arrhythmias and that the success of acute suppression is indicative of subsequent clinical control. Interim results of a recent trial of prophylaxis against recurrence of paroxysmal supraventricular tachycardia are reported, demonstrating a high efficacy with an acceptably low profile of adverse effects.
使用适当剂量时，索他洛尔对急性室上性心律失常的转复有效，基于该药物已知的电药理作用，这一效果是可预测的。电生理研究表明，口服和静脉注射索他洛尔在预防持续性心律失常的诱发方面均有效，且急性抑制的成功预示着后续的临床控制。本文报告了一项预防阵发性室上性心动过速复发的近期试验的中期结果，显示出高疗效且不良反应发生率可接受。
