Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan,
Int J Hematol. 2013 Oct;98(4):499-503. doi: 10.1007/s12185-013-1434-5. Epub 2013 Sep 15.
A 23-year-old woman developed acute severe hepatitis and jaundice on day 183 after bone marrow transplantation from HLA-B antigen mismatched-related donor. The administration of prednisolone and cessation of the prescribed drugs resolved the liver injury. Drug lymphocyte stimulation test was positive for acyclovir, and liver biopsy indicated the characteristics of drug-induced liver injury (DILI) rather than graft-versus-host disease. Physicians should keep DILI in mind when considering differential diagnosis for liver complications after allogeneic cell transplantation.
一位 23 岁女性在接受 HLA-B 抗原不匹配相关供者骨髓移植后 183 天出现急性重症肝炎和黄疸。应用泼尼松龙和停用规定药物后肝损伤得到缓解。药物淋巴细胞刺激试验提示阿昔洛韦阳性，肝活检提示药物性肝损伤（DILI）的特征，而非移植物抗宿主病。对于异基因细胞移植后肝脏并发症的鉴别诊断，医生应考虑到 DILI。
