Afrogheh Amir, Schneider Johann, Mohamed Noor, Hille Jos
Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa,
Head Neck Pathol. 2014 Jun;8(2):214-9. doi: 10.1007/s12105-013-0490-8. Epub 2013 Sep 14.
Clear cell calcifying epithelial odontogenic tumour (CCEOT) is a rare variant of calcifying epithelial odontogenic tumor (CEOT). While it is not surprising to find clear cells in odontogenic lesions, the exact nature of the clear cells in CCEOT has not been elucidated. Herein, we report a case of peripheral CCEOT of anterior mandible in a 37 year old black female. Histologically, the tumour consisted of cords and small nests of clear cells surrounded by dense deposits of amyloid and basophilic calcifications. The cells possessed abundant clear cytoplasm and eccentrically located indented nuclei. Admixed with the clear cells were eosinophilic cuboidal to polyhedral cells. The clear cells were PAS negative and immunoreactive for S100 protein, CD1a and Langerin. The clear cells were negative for MNF-116, SMA, Desmin and CK-19. It is therefore recommended to recognize two variants of CCEOT, namely, CEOT with clear cell change and CEOT with clear Langerhans cells (LC). We further suggest that the contradictory term "non-calcifying variant of calcifying epithelial odontogenic tumour with LC" to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.
透明细胞钙化上皮性牙源性肿瘤（CCEOT）是钙化上皮性牙源性肿瘤（CEOT）的一种罕见变异型。虽然在牙源性病变中发现透明细胞不足为奇，但CCEOT中透明细胞的确切性质尚未阐明。在此，我们报告一例37岁黑人女性下颌前部外周型CCEOT病例。组织学上，肿瘤由透明细胞索和小巢组成，周围有密集的淀粉样物质沉积和嗜碱性钙化。细胞具有丰富的透明细胞质和位于偏心位置的凹陷核。与透明细胞混合的是嗜酸性立方状至多面体细胞。透明细胞PAS染色阴性，对S100蛋白、CD1a和朗格汉斯细胞蛋白呈免疫反应。透明细胞对MNF-116、平滑肌肌动蛋白、结蛋白和细胞角蛋白19呈阴性。因此，建议认识到CCEOT的两种变异型，即具有透明细胞改变的CEOT和具有透明朗格汉斯细胞（LC）的CEOT。我们进一步建议摒弃“具有LC的钙化上皮性牙源性肿瘤的非钙化变异型”这一矛盾术语，因为当前病例清楚表明，无论有无钙化，LC均可在CEOT中见到。
