用于治疗焦虑症的新型靶向记忆与认知的药理学药物。
Novel pharmacological agents targeting memory and cognition in the treatment of anxiety disorders.
作者信息
Nandhra Harpal Singh, Murphy Catherine Louise, Sule Akeem
出版信息
Hum Psychopharmacol. 2013 Nov;28(6):538-43. doi: 10.1002/hup.2348.
OBJECTIVE
The aim of this study is to review data for several promising novel pharmacological drugs for anxiety disorders and describe how they exert their effects.
METHOD
We presented a review of the published literature. Online search plus reference list checking was also used.
RESULTS
The neurobiology of anxiety is overviewed. N-methyl-D-aspartate and beta adrenaline are involved in memory consolidation. We describe studies using memantine, D-cycloserine, propranolol, and riluzole that modulate these pathways.
CONCLUSION
There are a number of promising new therapies, but these require further studies before they can enter routine clinical practice.
目的
本研究旨在回顾几种用于治疗焦虑症的有前景的新型药理学药物的数据，并描述它们如何发挥作用。
方法
我们对已发表的文献进行了综述。还使用了在线搜索和参考文献列表检查。
结果
概述了焦虑的神经生物学。N-甲基-D-天冬氨酸和β肾上腺素参与记忆巩固。我们描述了使用美金刚、D-环丝氨酸、普萘洛尔和利鲁唑调节这些途径的研究。
结论
有许多有前景的新疗法，但在它们能够进入常规临床实践之前还需要进一步研究。
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