将生物催化与分子印迹相结合于仿生传感器中。
Coupling biocatalysis with molecular imprinting in a biomimetic sensor.
机构信息
Fraunhofer Institute for Biomedical Engineering, Am Mühlenberg 13, 14476 Potsdam (Germany); Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam (Germany).
出版信息
Angew Chem Int Ed Engl. 2013 Oct 25;52(44):11521-5. doi: 10.1002/anie.201305368. Epub 2013 Sep 5.
Make it simple: A molecularly imprinted electropolymer was combined with an enzyme in a catalytic biomimetic sensor that enabled interference-free detection of the drug aminopyrine (AP) at submicromolar concentrations in the presence of ascorbic acid and uric acid within 15 s. The sensor functioned by the peroxide-dependent conversion of AP in a layer above a product-imprinted electropolymer on an indicator electrode.
简单来说
将分子印迹电聚合体与酶结合到一个催化仿生传感器中，该传感器能够在 15 秒内实现对药物氨基比林（AP）的亚微摩尔浓度的无干扰检测，即使在抗坏血酸和尿酸存在的情况下也是如此。该传感器的功能是通过在指示剂电极上的产物印迹电聚合体上方的层中依赖过氧化物的 AP 转化来实现的。
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