Yarman Aysu, Kurbanoglu Sevinc
Molecular Biotechnology, Faculty of Science, Turkish-German University, Sahinkaya Cad. 86, Beykoz, Istanbul 34820, Turkey.
Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany.
Biomimetics (Basel). 2022 May 6;7(2):58. doi: 10.3390/biomimetics7020058.
Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played a major role worldwide. For this reason, various methods have been developed, comprising reverse transcriptase-polymerase chain reaction (RT-PCR), immunoassays, clustered regularly interspaced short palindromic repeats (CRISPR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and bio(mimetic)sensors. Among the developed methods, RT-PCR is so far the gold standard. Herein, we give an overview of the MIP-based sensors utilized since the beginning of the pandemic.
自2019年中国报告首例新型冠状病毒肺炎（COVID-19）病例以及世界卫生组织于2021年3月正式宣布其为大流行病以来，快速准确地诊断严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在全球范围内发挥了重要作用。因此，人们开发了各种方法，包括逆转录聚合酶链反应（RT-PCR）、免疫测定、成簇规律间隔短回文重复序列（CRISPR）、逆转录环介导等温扩增（RT-LAMP）和生物（仿生）传感器。在已开发的方法中，RT-PCR是迄今为止的金标准。在此，我们概述了自疫情开始以来所使用的基于分子印迹聚合物（MIP）的传感器。
