Department of Forensic Medicine, Medical University of Gdansk, ul. Debowa 23, 80-204 Gdansk, Poland.
CNS Neurol Disord Drug Targets. 2013 Nov;12(7):930-5. doi: 10.2174/18715273113129990094.
We report recent postmortem findings from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA transcriptional activity have been revealed by the quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). Abnormalities in AgNOR parameters have been found in neurons of the prefrontal limbic regions, the amygdala, the external globus pallidus, and the serotonergic dorsal raphe nucleus (DRN). The impact of the processes leading to suicide has been clearly accentuated in opposition to the weak influence of unipolar-bipolar dichotomy, which was only revealed in one area (the anterior cingulate cortex). The impact of suicide was most pronounced in the DRN. Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide.
我们报告了马格德堡脑库最近的尸检结果，这些结果与评估与抑郁相关的神经元网络活动障碍有关。通过对银染核仁组成区（AgNOR）的定量评估，揭示了核糖体 DNA 转录活性的慢性变化。在前额叶边缘区域、杏仁核、外苍白球和 5-羟色胺能背侧中缝核（DRN）的神经元中发现了 AgNOR 参数的异常。与单相双相二分法的微弱影响相反，导致自杀的过程的影响明显加重，而单相双相二分法仅在一个区域（前扣带回皮质）中显示。自杀的影响在 DRN 中最为明显。我们的 AgNOR 研究表明，抗精神病药物（抗抑郁药和典型的神经阻滞剂等）在预防特定于自杀的异常神经元活动方面的影响是有限的。
