Guagliardi L E, Koppelman B, Blum J S, Marks M S, Cresswell P, Brodsky F M
Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143.
Nature. 1990 Jan 11;343(6254):133-9. doi: 10.1038/343133a0.
The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.
免疫电子显微镜已明确了参与抗原加工与呈递的细胞内运输途径。II类组织相容性分子的输出途径与抗原输入途径在一个外周内吞区室交汇，该区域具备所有据信抗原加工与呈递所需的分子机制，包括内化的表面免疫球蛋白、蛋白水解酶和恒定链。这个区室界定了一个位点，内吞抗原产生的肽段可在此与II类分子结合，进而转运至细胞表面以呈递给T细胞。
