Sector of Neuropsychology for Children and Adolescents, Brain Center Rudolf Magnus, University Medical Center Utrecht, Room KG 01.327.1, P.O. Box 85090, 3508 AB Utrecht, The Netherlands; Bio Research Center for Children, Wekeromseweg 8, 6816 VS Arnhem, The Netherlands.
Epilepsy Res. 2013 Nov;107(1-2):146-55. doi: 10.1016/j.eplepsyres.2013.08.017. Epub 2013 Sep 2.
To investigate verbal memory after epilepsy surgery both group-wise and at the level of individual children, and to assess associations with side of surgery and removal of the temporal lobe.
A prospective controlled study in a consecutive sample of 21 children undergoing epilepsy surgery, with comprehensive assessments of verbal memory before surgery and six, 12 and 24 months after surgery. For each patient, two age- and gender-matched controls were tested at similar intervals. Standardized regression-based (SRB) analysis was applied to compare post-surgical change in individual patients with change in controls.
Group-wise, average normed scores on verbal memory tests were higher after epilepsy surgery than before, corroborating earlier reports. By dint of empirically based SRB analysis, however, considerable individual differences in post-surgical change were revealed. Children with resections that included the left temporal lobe functioned significantly poorer than predicted on the basis of their pre-surgical performance. In contrast, verbal memory performance after surgery was consistent with pre-surgical baseline in the majority of children with resections that spared the left temporal lobe.
Despite cessation of epileptic seizures, verbal memory remains vulnerable in children who required surgery including the left temporal lobe. In most - but not all - children with other types of surgery, post-surgical verbal memory is consistent with their individual pre-surgical base level.
在群组和个体儿童层面上，研究癫痫手术后的言语记忆，并评估其与手术侧和颞叶切除的相关性。
对 21 名接受癫痫手术的连续样本进行前瞻性对照研究，在手术前、手术后 6、12 和 24 个月进行全面的言语记忆评估。每个患者都在相似的时间间隔接受了两个年龄和性别匹配的对照组的测试。应用基于标准化回归的（SRB）分析比较个体患者术后变化与对照组变化。
在群组层面上，言语记忆测试的平均标准化分数在癫痫手术后高于手术前，这与早期的报告相符。然而，通过基于经验的 SRB 分析，揭示了术后变化的个体差异很大。包括左侧颞叶切除的儿童术后表现明显不如基于术前表现的预测。相比之下，在大多数保留左侧颞叶的手术儿童中，术后言语记忆与术前基线一致。
尽管癫痫发作停止，包括左侧颞叶在内的手术儿童的言语记忆仍然容易受到影响。在大多数（但不是全部）接受其他类型手术的儿童中，术后言语记忆与他们的个体术前基础水平一致。
