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日本6至8岁小学生阻塞性睡眠呼吸暂停综合征的患病率。

Prevalence of obstructive sleep apnea syndrome in Japanese elementary school children aged 6-8 years.

作者信息

Kitamura Takuro, Miyazaki Soichiro, Kadotani Hiroshi, Suzuki Hideaki, Kanemura Takashi, Komada Ichiro, Nishikawa Michiko, Kobayashi Ryuichi, Okawa Masako

机构信息

Department of Sleep Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan,

出版信息

Sleep Breath. 2014 May;18(2):359-66. doi: 10.1007/s11325-013-0893-5. Epub 2013 Sep 17.

Abstract

PURPOSE

We aimed to determine the prevalence of and the risk factors for obstructive sleep apnea syndrome (OSAS) in Japanese children aged 6-8 years.

METHODS

The parents of 202 children aged 6-8 years who attended a single elementary school in Shiga, Japan, were requested to complete the Child and Adolescent Sleep Checklist (CASC) and perform home Type 3 portable monitoring of their children. By using the CASC data and monitor recordings, we estimated the prevalence of pediatric OSAS with the help of different diagnostic criteria and identified the risk factors associated with OSAS.

RESULTS

Complete data were obtained from 170 of the 194 children whose parents participated in the study. The mean total apnea-hypopnea index and obstructive apnea hypopnea index were 1.4 ± 1.3 and 0.4 ± 0.6 h(-1), respectively, and central apnea was the most prevalent type of respiratory event, accounting for 70.4% of all events. The overall prevalence of OSAS ranged from 0.6% to 43.5%, depending on the cutoff value used, and was 3.5% when using International Criteria of Sleep Disorders version II (ICSD II) diagnostic criteria. The presence of tonsillar hypertrophy was the only parameter whose prevalence was significantly elevated in children with OSAS across all diagnostic criteria.

CONCLUSIONS

The prevalence of pediatric OSAS varies according to the diagnostic criteria used, indicating the need for further research focusing on outcomes to define a clinically significant diagnostic threshold. The presence of tonsillar hypertrophy is an important risk factor in the development of pediatric OSAS.

摘要

目的

我们旨在确定日本6至8岁儿童阻塞性睡眠呼吸暂停综合征(OSAS)的患病率及其危险因素。

方法

要求日本滋贺县一所小学的202名6至8岁儿童的家长填写儿童与青少年睡眠检查表(CASC),并对其子女进行家庭3型便携式监测。通过使用CASC数据和监测记录,我们借助不同的诊断标准估算了小儿OSAS的患病率,并确定了与OSAS相关的危险因素。

结果

194名家长参与研究的儿童中,有170名获得了完整数据。平均总呼吸暂停低通气指数和阻塞性呼吸暂停低通气指数分别为1.4±1.3和0.4±0.6次/小时,中枢性呼吸暂停是最常见的呼吸事件类型,占所有事件的70.4%。根据所使用的临界值,OSAS的总体患病率在0.6%至43.5%之间,使用国际睡眠障碍分类第二版(ICSD II)诊断标准时为3.5%。扁桃体肥大是唯一在所有诊断标准下OSAS儿童中患病率显著升高的参数。

结论

小儿OSAS的患病率因所使用的诊断标准而异,这表明需要进一步开展侧重于结局的研究,以确定具有临床意义的诊断阈值。扁桃体肥大的存在是小儿OSAS发生的一个重要危险因素。

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