大脑中的细胞外信号调节激酶1/2介导中枢抵抗素对降低棕色脂肪组织产热的影响。
ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue.
作者信息
Kosari Samin, Camera Donny M, Hawley John A, Stebbing Martin, Badoer Emilio
机构信息
School of Medical Sciences and Health Innovations Research Institute, RMIT University Melbourne, Australia.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2013 Sep 10;5(3):184-9. eCollection 2013.
Abstract
We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7 μg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 μg) (P < 0.05). Resistin reduced uncoupling protein-1 mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain contributes to resistin's effects on thermogenesis.
摘要
我们研究了大脑中细胞外信号调节激酶1/2（ERK1/2）在中枢给予抵抗素对产热影响中的作用。向麻醉大鼠注射抵抗素（7微克）可使棕色脂肪组织温度显著降低1.0±0.4℃（P<0.005）。当用U0126（7微克）抑制ERK1/2时，这种反应显著减弱了60%以上（P<0.05）。抵抗素降低了解偶联蛋白-1 mRNA表达（抵抗素组与对照组分别为0.11±0.01和1.24±0.85）以及过氧化物酶体增殖物激活受体γ共激活因子1-α的表达，但这些影响无统计学意义。结果表明，大脑中的ERK1/2参与了抵抗素对产热的影响。
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