Department of Surgery, School of Medicine, Health Sciences University of Mongolia and ADAM Urology and Andrology Clinic, Ulaanbaatar, Mongolia.
World J Mens Health. 2013 Aug;31(2):170-5. doi: 10.5534/wjmh.2013.31.2.170. Epub 2013 Aug 31.
To detect the testosterone deficiency syndrome in Mongolian men over 40 years old with erectile dysfunction (ED).
Total of 309 males over 40 years of age who received medical care at the ADAM Urology and Andrology Clinic from 2010 to 2011 were included in this study. An approval from the Ethics Committee of the Ministry of Health of Mongolia was obtained, and each study participant signed a consent form at the beginning of the study. The participants were assigned to either an ED group or a control group, depending on the results of the international index of erectile function (IIEF)-5 questionnaire. The ED group was further divided into three groups (moderate, severe, and very severe) based on the level of ED. The total testosterone (TT) levels were determined in the blood serum using a competitive enzyme-linked immunesorbent assay (ELISA) analytical system UBI Magiwel™ Testosterone Quantitative test, and free testosterone (FT) calculated as described by the Vermeulen calculation. Test samples were collected between 8:00 and 11:00 am in the mornings and testosterone deficiency syndrome was diagnosed based on the International Society for the Study of the Aging Male guidelines, particularly, if TT was ≤3.46 ng/ml or free testosterone FT was ≤0.072 ng/ml.
ED of moderate, severe, and very severe levels was diagnosed in 199 (64.41%) out of 309 participants. There was an inverse relationship between the main IIEF-5 score and age (r=-0.380, p<0.01). The average TT was 5.75±2.316 ng/ml and FT was 0.091±0.0084 ng/ml. Compared to the ED group, the control group had a higher TT level: 5.6440±1.177 ng/ml and 5.812±2.316 ng/ml, respectively. In the control group, the FT level was 0.061±0.0084 ng/ml, whereas it was 0.041±0.0076 ng/ml in the ED group.
Our study showed that most of the aging males who came to the clinic had moderate to very severe ED (64.55%). The levels of TT (5.644±1.177 ng/ml) and FT (0.041±0.0036 ng/ml) were significantly lower in ED patients (p<0.05). The testosterone deficiency syndrome was detected in 24.27% of the ED group.
检测 40 岁以上蒙古男性勃起功能障碍（ED）患者的睾酮缺乏综合征。
2010 年至 2011 年期间，共有 309 名 40 岁以上在 ADAM 泌尿科和男科诊所接受治疗的男性纳入本研究。本研究获得了蒙古卫生部伦理委员会的批准，每位研究参与者在研究开始时都签署了同意书。根据国际勃起功能指数（IIEF）-5 问卷的结果，将参与者分配到 ED 组或对照组。ED 组根据 ED 程度进一步分为中度、重度和极重度三组。使用竞争酶联免疫吸附分析系统 UBI Magiwel™ Testosterone Quantitative test 测定血清中的总睾酮（TT）水平，并根据 Vermeulen 计算法计算游离睾酮（FT）。测试样本在上午 8：00 至 11：00 之间采集，根据国际男性衰老研究学会的指南诊断睾酮缺乏综合征，特别是 TT≤3.46ng/ml 或游离睾酮 FT≤0.072ng/ml。
309 名参与者中，199 名（64.41%）诊断为中、重度和极重度 ED。主要 IIEF-5 评分与年龄呈负相关（r=-0.380，p<0.01）。平均 TT 为 5.75±2.316ng/ml，FT 为 0.091±0.0084ng/ml。与 ED 组相比，对照组 TT 水平更高：5.6440±1.177ng/ml 和 5.812±2.316ng/ml。对照组 FT 水平为 0.061±0.0084ng/ml，而 ED 组为 0.041±0.0076ng/ml。
我们的研究表明，大多数来诊所就诊的老年男性都有中度至重度 ED（64.55%）。ED 患者的 TT（5.644±1.177ng/ml）和 FT（0.041±0.0036ng/ml）水平明显较低（p<0.05）。ED 组中检测到 24.27%的睾酮缺乏综合征。
