Fort Kyle L, Silveira Joshua A, Russell David H
Department of Chemistry, Texas A&M University , College Station, Texas 77843, United States.
Anal Chem. 2013 Oct 15;85(20):9543-8. doi: 10.1021/ac401629b. Epub 2013 Oct 3.
Simulation-based development and experimental characterization of a DC-only ion funnel is described herein. Radial ion confinement is achieved via periodic focusing whereby a collisionally dampened effective potential is generated in the inertial frame of an ion traversing the device with appreciable velocity. The new device, termed a periodic focusing ion funnel (PF IF), provides an efficient alternative to the rf ion funnel providing high ion transmission with fewer electrodes, simplified electrical circuitry, and reduced power supply requirements. The utility of the PF IF for structural ion mobility-mass spectrometry (IM-MS) studies is demonstrated using model peptide ions (bradykinin, gramicidin S, and trpzip 1).
