Greengard O
Biol Neonate. 1975;27(5-6):352-60. doi: 10.1159/000240792.
Cortisol treatment of neonatal rats did not have permanent effects on the levels of 2-7 enzymes in heart, kidney, brain, and liver, even though some exhibited abnormally high concentrations during the first 1 or 2 weeks. An injection of cortisol at birth evoked premature rises of glucose-6-phosphatase (G6P-ase) in kidney, of soluble and particulate aspartate aminotransferase (AAT) in kidney and heart and of soluble AAT in liver. These enzymes (with the exception of soluble AAT in the female) did not respond to cortisol in adult rats. The significance of the varying effects of cortisol is discussed in relation to previously studied developmental enzyme formations.
对新生大鼠进行皮质醇治疗，对心脏、肾脏、大脑和肝脏中2 - 7种酶的水平没有永久性影响，尽管在最初1或2周内有些酶的浓度异常高。出生时注射皮质醇会导致肾脏中葡萄糖-6-磷酸酶（G6P-ase）、肾脏和心脏中可溶性和颗粒性天冬氨酸转氨酶（AAT）以及肝脏中可溶性AAT过早升高。这些酶（雌性大鼠中的可溶性AAT除外）在成年大鼠中对皮质醇没有反应。结合先前研究的发育性酶形成情况，讨论了皮质醇不同作用的意义。
