McGuire G P, Pearl R G
Department of Anesthesia, Stanford University Medical Center, California.
Crit Care Clin. 1990 Jan;6(1):121-46.
Conventional therapy for septic shock concentrates on correcting circulatory perfusion defects by optimizing hemodynamic parameters and oxygen delivery to the periphery. In the face of ongoing sepsis, the central abnormality of nutrient acquisition and energy production at the cellular level remains and the patient often progresses to MSOF despite our best efforts. Currently, surgical drainage and antibiotic therapy are the mainstays for eradication of infection. In the future, as we understand more of the mediators and metabolic consequences of septic shock, we anticipate that a more specific, directed therapy will be developed to reduce the high mortality rate.
感染性休克的传统治疗集中于通过优化血流动力学参数和向周围组织输送氧气来纠正循环灌注缺陷。面对持续的脓毒症，细胞水平上营养获取和能量产生的核心异常依然存在，尽管我们尽了最大努力，患者仍常进展为多器官功能障碍综合征。目前，手术引流和抗生素治疗是根除感染的主要手段。未来，随着我们对感染性休克的介质和代谢后果有更多了解，我们预计将开发出更具特异性、针对性的治疗方法以降低高死亡率。
