Prabhakar M C, Santhikrupa D, Manasa N, Rao O Umamaheswar
Shri Vishnu College of Pharmacy, Bhimavaram, Andhrapradesh, India.
Indian J Lepr. 2013 Jan-Mar;85(1):5-9.
Oxidative stress is a condition associated with an increased rate of cellular damage induced by the oxygen derived oxidants commonly known as reactive oxygen species (ROS). ROS are capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. Severe oxidative stress has been reported in leprosy patients because of malnutrition and poor immunity. The decreased levels of SOD, glutathione and total antioxidant status in leprosy patients may indicate a degradation of these antioxidant enzymes by free radicals during detoxification processes. The subjects for this study comprises of Normal human volunteers (NHV, n = 20) and treated MB patients (MB, n = 20). The levels of lipid peroxidation products are increased in MB Patients (*P < 0.001). SOD (**P < 0.0001) and glutathione levels (***P < 0.0001) decreased in MB Patients in comparision with normal human volunteers. The present study of estimation of antioxidants conclude that the free radical activity was increased and the total antioxidant status was decreased in all MB patients, indicating that there was an oxidative stress even after the treatment with MDT. The decreased levels of SOD, glutathione indicate a link between oxidative stress and leprosy. Since the MB patients are unable to produce sufficient amount of antioxidant to cope up with the increased oxidative stress in them. Providing nutritional supplementation may present a novel approach for fast recovery. Administration of exogenous antioxidants like vitamin C, tocopherols would prevent tissue damage and make the patient therapeutically benefited.
氧化应激是一种与细胞损伤速率增加相关的状态，这种损伤由通常被称为活性氧（ROS）的氧衍生氧化剂引起。ROS能够破坏在麻风病的慢性、炎症性、神经退行性疾病过程中过量产生的细胞成分。由于营养不良和免疫力低下，麻风病患者中已报道存在严重的氧化应激。麻风病患者中超氧化物歧化酶（SOD）、谷胱甘肽水平和总抗氧化状态的降低可能表明在解毒过程中这些抗氧化酶被自由基降解。本研究的受试者包括正常人类志愿者（NHV，n = 20）和接受治疗的多菌型（MB）患者（MB，n = 20）。MB患者中脂质过氧化产物水平升高（*P < 0.001）。与正常人类志愿者相比，MB患者中SOD（**P < 0.0001）和谷胱甘肽水平（***P < 0.0001）降低。本次对抗氧化剂的评估研究得出结论，所有MB患者的自由基活性增加而总抗氧化状态降低，这表明即使在接受多药联合化疗（MDT）治疗后仍存在氧化应激。SOD、谷胱甘肽水平的降低表明氧化应激与麻风病之间存在联系。由于MB患者无法产生足够量的抗氧化剂来应对其体内增加的氧化应激。提供营养补充可能是一种促进快速康复的新方法。给予外源性抗氧化剂如维生素C、生育酚将预防组织损伤并使患者在治疗上受益。
