Witting C, Detlefsen W
Blut. 1975 Oct;31(4):229-38. doi: 10.1007/BF01633506.
The early phase of graft-versus-host-reaction is characterized by a rapid decline of lymphocytes in the peripheral blood, with a minimum between days 9 and 11, and return to normal until day 20 after spleen cell grafting. Erythrocytes and hematocrit do not change during this period. There is no causal correlation between splenomegaly and lymphopenia. Lymphopenia provides a criterium for experimental graft-versusu-host-reaction equivalent to the spleen-index.
移植物抗宿主反应的早期阶段，其特征是外周血淋巴细胞迅速减少，在第9至11天之间降至最低，然后在脾细胞移植后直到第20天恢复正常。在此期间，红细胞和血细胞比容没有变化。脾肿大与淋巴细胞减少之间没有因果关系。淋巴细胞减少为实验性移植物抗宿主反应提供了一个与脾脏指数相当的标准。
