Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia.
CNS Neurol Disord Drug Targets. 2013 Sep;12(6):750-62. doi: 10.2174/18715273113126660171.
Diffuse and unstoppable infiltration of brain and spinal cord tissue by neoplastic glial cells is the single most important therapeutic problem posed by the common glioma group of tumors: astrocytoma, oligoastrocytoma, oligodendroglioma, their malignant variants and glioblastoma. These neoplasms account for more than two thirds of all malignant central nervous system tumors. However, most glioma research focuses on an examination of the tumor cells rather than on host-specific, tumor micro-environmental cells and factors. This can explain why existing diffuse glioma therapies fail and why these tumors have remained incurable. Thus, there is a great need for innovation. We describe a novel strategy for the development of a more effective treatment of diffuse glioma. Our approach centers on gaining control over the behavior of the microglia, the defense cells of the CNS, which are manipulated by malignant glioma and support its growth. Armoring microglia against the influences from glioma is one of our research goals. We further discuss how microglia precursors may be genetically enhanced to track down infiltrating glioma cells.
肿瘤性神经胶质细胞弥漫性和不可阻挡地浸润脑和脊髓组织，是常见神经胶质瘤组肿瘤（星形细胞瘤、少突星形细胞瘤、少突胶质细胞瘤、其恶性变体和胶质母细胞瘤）提出的单一最重要的治疗问题。这些肿瘤占所有恶性中枢神经系统肿瘤的三分之二以上。然而，大多数神经胶质瘤研究侧重于检查肿瘤细胞，而不是宿主特异性、肿瘤微环境细胞和因素。这可以解释为什么现有的弥漫性神经胶质瘤疗法失败，以及为什么这些肿瘤仍然无法治愈。因此，非常需要创新。我们描述了一种治疗弥漫性神经胶质瘤的更有效治疗方法的新策略。我们的方法集中在控制中枢神经系统的防御细胞——小胶质细胞的行为上，恶性神经胶质瘤可以操纵小胶质细胞并支持其生长。使小胶质细胞免受来自神经胶质瘤的影响是我们的研究目标之一。我们进一步讨论了如何通过基因增强小胶质细胞前体来追踪浸润性神经胶质瘤细胞。
