[1例食管癌合并脓毒症性弥散性血管内凝血患者在放化疗期间接受重组人可溶性血栓调节蛋白治疗的病例]
[A case of esophageal cancer with septic disseminated intravascular coagulation treated with recombinant human soluble thrombomodulin during chemoradiation therapy].
作者信息
Sasaki Ken, Okumura Hiroshi, Uchikado Yasuto, Minami Koji, Ijichi Tetsuya, Owaki Tetsuhiro, Ishigami Sumiya, Natsugoe Shoji
机构信息
Dept. of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, Japan.
出版信息
Gan To Kagaku Ryoho. 2013 Sep;40(9):1213-5.
A 70-year-old woman was diagnosed with synchronous advanced esophageal cancer and early renal cancer. During chemoradiation therapy for the esophageal cancer, she suffered from septic shock due to pneumonia. She got worse despite the administration of antibiotics and gglobulin. On the following day, she was diagnosed with septic disseminated intravascular coagulation(DIC)on the basis of the diagnostic criterion for acute DIC. Recombinant human soluble thrombomodulin(rTM) was administered to treat the DIC. The patient responded promptly to rTM treatment and recovered from the DIC in just 1 day. rTM is thought to be an effective drug for sepsis-induced DIC during chemoradiation therapy.
一名70岁女性被诊断为同时患有晚期食管癌和早期肾癌。在对食管癌进行放化疗期间，她因肺炎引发感染性休克。尽管使用了抗生素和球蛋白，她的病情仍恶化。次日，根据急性弥散性血管内凝血（DIC）的诊断标准，她被诊断为感染性弥散性血管内凝血。给予重组人可溶性血栓调节蛋白（rTM）治疗DIC。患者对rTM治疗反应迅速，仅1天就从DIC中康复。rTM被认为是放化疗期间治疗脓毒症诱发DIC的有效药物。
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