Kawamoto Hiroshi, Uchida Yoichiro, Ueda Shugo, Yanagita Soshi, Terajima Hiroaki
Dept. of Gastroenterological Surgery and Oncology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital.
Gan To Kagaku Ryoho. 2015 Mar;42(3):363-5.
A 62-year-old man, who underwent distal gastrectomy due to gastric cancer, was diagnosed with disseminated carcinomatosis of the bone marrow 8 years later. Chemotherapy was administered following treatment with recombinant human soluble thrombomodulin (rTM), and as a result, he successfully recovered from his disseminated intravascular coagulation (DIC) status and experienced improvement of his severe cancer-related pain. The use of rTM may enable the safe continuation of chemotherapy, and rTM may also be a useful treatment for DIC associated with solid cancer, such as gastric cancer.
一名62岁男性因胃癌接受了远端胃切除术,8年后被诊断为骨髓播散性癌病。在用重组人可溶性血栓调节蛋白(rTM)治疗后进行了化疗,结果,他成功从弥散性血管内凝血(DIC)状态中恢复,并经历了严重癌症相关疼痛的改善。rTM的使用可能使化疗得以安全持续,并且rTM也可能是治疗与实体癌(如胃癌)相关的DIC的有效方法。