Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
J Hum Genet. 2013 Nov;58(11):742-8. doi: 10.1038/jhg.2013.95. Epub 2013 Sep 19.
Esophageal cancer (EC), mainly consisting of squamous cell carcinoma (ESCC) in the Eastern world and adenocarcinoma (EAC) in the Western world, is strongly associated with dietary factors such as alcohol use. We aimed to clarify the modifying role in EC etiology in Caucasians of functional genotypes in alcohol-metabolizing enzymes. In all, 351 Caucasian patients with EC and 430 matched controls were included and polymorphisms in CYP2E1, ADH and near ALDH2 genes were determined. In contrast to the results on ESCC in mainly Asian studies, we found that functional genotypes of alcohol-metabolizing enzymes were not significantly associated with EAC or ESCC in an European population.
食管癌（EC）主要包括东方世界的鳞状细胞癌（ESCC）和西方世界的腺癌（EAC），与饮食因素密切相关，如饮酒。我们旨在阐明在白种人群中，酒精代谢酶的功能基因型在 EC 病因学中的修饰作用。共纳入 351 例白种人 EC 患者和 430 例匹配对照，并确定 CYP2E1、ADH 和附近 ALDH2 基因的多态性。与主要在亚洲研究中 ESCC 的结果相反，我们发现，在欧洲人群中，酒精代谢酶的功能基因型与 EAC 或 ESCC 并无显著相关性。
