Metabolic Bone Disease, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA,
Curr Osteoporos Rep. 2013 Sep;11(3):179-87. doi: 10.1007/s11914-013-0167-y.
Bisphosphonates are the most commonly used drugs worldwide for treating osteoporosis. Atypical femoral fractures most commonly are associated with prolonged bisphosphonate use. They also may occur with denosumab use or in patients without a history of using these drugs. In this article, we provide a comprehensive review of the mechanism of action of bisphosphonate and the definition, incidence, epidemiology, pathogenesis, diagnosis, management, and prevention of atypical femoral fractures.
双膦酸盐是目前全球范围内治疗骨质疏松症最常用的药物。非典型股骨骨折最常与长期使用双膦酸盐相关。它们也可能发生在使用地舒单抗或无这些药物使用史的患者中。本文全面综述了双膦酸盐的作用机制以及非典型股骨骨折的定义、发生率、流行病学、发病机制、诊断、治疗和预防。
