Department of Neurology & Neurosurgery, Department of Psychiatry, and Department of Psychology, McGill University, Montreal, Quebec H3A 0G4, Canada, Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2R7, Canada, and Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
J Neurosci. 2013 Sep 18;33(38):15285-94. doi: 10.1523/JNEUROSCI.5029-12.2013.
The meso-striatal dopamine system influences responses to rewards and the motivation to seek them out. Marked individual differences in these responses are seen in laboratory animals, related in part to input from the prefrontal cortex. Here we measured the relation between cortical morphology and drug-induced striatal dopamine release in healthy young people. Participants were 24 (17 male, 7 female; age 23.0 ± 6.2 years) stimulant drug-naive subjects who underwent PET [(11)C]raclopride scans with 0.3 mg/kg d-amphetamine orally and placebo, and an anatomical MRI scan for measuring cortical thickness. As expected, d-amphetamine produced significant reductions in [(11)C]raclopride binding potential in the striatum as a percentage of the value in the placebo condition. There was substantial individual variability in this response, which was correlated with cortical thickness in the frontal lobe as a whole. The association was strongest in the anterior part of the right lateral prefrontal cortex and bilateral supplementary motor area. A thicker cortex was correlated with a smaller dopamine response. Together, this work demonstrates in humans an association between cortical thickness and the striatal dopamine response to drugs of abuse. Although prefrontal regulation of striatal function has been well studied, it was unclear whether the thickness of the prefrontal cortex was an acceptable proxy to the function of that region. These results suggest it is.
中脑边缘多巴胺系统影响对奖励的反应和寻求奖励的动机。在实验室动物中可以看到这些反应存在明显的个体差异，部分原因是来自前额叶皮层的输入。在这里，我们测量了健康年轻人的皮质形态与药物诱导的纹状体多巴胺释放之间的关系。参与者为 24 名（17 名男性，7 名女性；年龄 23.0 ± 6.2 岁）无兴奋剂药物使用史的受试者，他们接受了 PET [(11)C]raclopride 扫描，口服 0.3mg/kg d-苯丙胺和安慰剂，以及用于测量皮质厚度的解剖 MRI 扫描。正如预期的那样，d-苯丙胺使纹状体中的[(11)C]raclopride 结合潜力相对于安慰剂条件下的数值显著降低。这种反应存在很大的个体差异，与额叶皮质的整体厚度有关。这种关联在右侧外侧前额叶皮质的前部和双侧辅助运动区最为强烈。皮质越厚，多巴胺反应越小。总的来说，这项工作在人类中证明了皮质厚度与药物滥用引起的纹状体多巴胺反应之间存在关联。虽然已经对前额叶对纹状体功能的调节进行了充分研究，但尚不清楚前额叶皮质的厚度是否可以作为该区域功能的替代指标。这些结果表明，这是可以的。
